Discovery – Principal Scientist (Antibody Discovery and Engineering)

Function: 

Discovery

Primary Function:

Design and validate novel antibody therapeutics using various tools like computer modeling, high-throughput screening and multiple display technologies.

Major Responsibilities and Duties:

The successful candidate is expected to:

  • Demonstrate leadership and critical thinking skills, and most importantly, passion to contribute to making new medicines to treat ophthalmic diseases.
  • Oversee part of or the whole protein discovery and engineering team in terms of work arrangement, data analysis and troubleshooting.
  • Summarize research results in publication quality figures and report results to function head.
  • Maintain high quality experimental records.
  • Establish and validate new SOPs and update current ones.
  • Be up to date with current industrial and academic progress by self-motivated reading and other ways of exploration.
  • Design and validate novel protein therapeutics, in particular, bispecific antibodies, using multiple tools.
  • Perform high-throughput antibody screening and engineering for drug discovery.
  • Small-scale high-throughput protein expression and purification.
  • Characterization of proteins, including but not limited to SDS-PAGE, SEC, Western blot, cIEF, etc.
  • Be open-minded, resourceful and innovative; more importantly, have passion to contribute to the perfection of antibody engineering platform.
  • Well-organized and self-motivated, with high team spirit and a keen interest in learning.
  • Communicate timely and effectively with function head.

Qualifications:

  1. A PhD degree with at least 2 years working experience in protein engineering and/or protein structure studies.
  2. Expert in protein expression and purification systems, especially AKTA.
  3. Expert in protein analysis methods, e.g., thermostability, cIEF, SEC, HIC, LC-MS, etc.
  4. Familiar with basic molecular work like PCR, real-time PCR, cloning, SDS-PAGE, etc.
  5. Good academic writing skills in English.
  6. Good verbal and written communication skills, both English and Chinese.