A common feature of DR is the formation of microaneurysms or weak spots in the retinal blood vessels that can leak fluid and bleed. Bleeding complications and swelling of the retina can lead to the formation of scar tissue and permanent vision loss. Key risk factors for the development of DME is the severity of DR, duration of diabetes, and adequate control of blood glucose.
Despite the availability of anti-VEGF drugs to treat DR/DME, many patients have only partial response and require frequent injections. An unmet need exists for newer treatments that can improve efficacy and durability of response.