Eye disease associated with diabetes (Type I or II) is referred to as diabetic retinopathy (DR) and is a leading cause of vision loss in people under age 50.
Diabetic macular edema (DME) is a condition of the retina where there is excessive fluid leakage from the blood vessels in the eye that leads to swelling of the retina and subsequent vision loss. DR can occur with or without the presence of DME.
Diabetic macular edema (DME) is a condition of the retina where there is excessive fluid leakage from the blood vessels in the eye that leads to swelling of the retina and subsequent vision loss. DR can occur with or without the presence of DME.
A common feature of DR is the formation of microaneurysms or weak spots in the retinal blood vessels that can leak fluid and bleed. Bleeding complications and swelling of the retina can lead to the formation of scar tissue and permanent vision loss. Key risk factors for the development of DME is the severity of DR, duration of diabetes, and adequate control of blood glucose.
Despite the availability of anti-VEGF drugs to treat DR/DME, many patients have only partial response and require frequent injections. An unmet need exists for newer treatments that can improve efficacy and durability of response.
Retina with DR/DME
Cross-section of a retina with DR/DME showing retinal thickening (gray area) due to swelling, microaneurysms, and multiple retinal bleeding (hemorrhages).
Fundoscopic image shows multiple areas of hemorrhages
The OCT image demonstrates an abnormally thickened and distorted macula with fluid accumulation.