Retinal vein occlusion (RVO) is a condition of the eye where a blockage occurs in a retinal blood vessel that normally drains the blood back into the circulation.
When the vein is blocked, it cannot drain blood from the retina and can lead to bleeding and/or accumulation of excess fluid (macular edema). There are two types of RVO conditions: central retinal vein occlusion (CRVO) where the blockage is the main retinal vein; and branch retinal vein occlusion (BRVO) where there is blockage of a smaller branched vein.
Swelling of the retinal tissue and bleeding can lead to vision loss and permanent vision loss. Despite the availability of anti-VEGF drugs to treat RVO, many patients have only partial response and require frequent injections. An unmet need exists for newer treatments that can improve efficacy and durability of response.